Author: aniagrodsky
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Replicative Crisis: Mapping Cellular Fates and Identifying Determinants between Cell Survival and Death
In order to divide indefinitely, most cancerous cells activate the enzyme telomerase, which elongates telomeres. To express telomerase, cells typically survive a state known as replicative crisis. This work explores two areas critical to understanding crisis-related mechanisms: the generation of chromosomal aberrations and cytosolic DNA species during crisis and determinants of cell death versus survival…
