Author: Nihitha Reddy
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BRCA2’s Relation with Aldehydes Leads to a Higher Risk of Developing Prostate Cancer Than BRCA1
This retrospective analysis research paper discusses why the difference between the responses of aldehyde exposure from patients with a heterozygous germline mutation in BRCA2 and BRCA1 leads to a higher risk of prostate cancer in BRCA2 mutant carriers than BRCA1.
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BRCA2’s Relation with Aldehydes Leads to a Higher Risk of Developing Prostate Cancer Than BRCA1
Abstract: Although two of the most significant breast cancer susceptibility proteins, BRCA1 and BRCA2, interact with each other in the same DNA damage repair (DDR) pathway (BRCA1 works in checkpoint activation and DNA repair, and BRCA2 plays a major role in homologous recombination), they react differently when exposed to aldehydes. Aldehydes, RCHO, have a more…
Youth Medical Journal 